| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM20120 |
|---|
| Substrate/Competitor | BDBM20130 |
|---|
| Meas. Tech. | Papain Inhibition Assay |
|---|
| Ki | 300±n/a nM |
|---|
| Citation |  Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem48:7688-707 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36975.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43235 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM20120 |
|---|
| BDBM20130 |
|---|
| Name | BDBM20120 |
|---|
| Synonyms: | (2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)formamido]propanamide | phenylalanine derivative, 44 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21N3O2 |
|---|
| Mol. Mass. | 383.4424 |
|---|
| SMILES | O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
