Reaction Details |
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Target | Signal transducer and activator of transcription 3 |
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Ligand | BDBM20233 |
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Substrate/Competitor | BDBM20194 |
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Meas. Tech. | Fluorescence Polarization Assay |
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IC50 | 409±n/a nM |
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Citation | Coleman, DR; Ren, Z; Mandal, PK; Cameron, AG; Dyer, GA; Muranjan, S; Campbell, M; Chen, X; McMurray, JS Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. J Med Chem48:6661-70 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Signal transducer and activator of transcription 3 |
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Name: | Signal transducer and activator of transcription 3 |
Synonyms: | Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3 |
Type: | Cytosolic Transcription Factor |
Mol. Mass.: | 88050.28 |
Organism: | Mus musculus (mouse) |
Description: | Bacterially expressed protein was used in the FP assay. |
Residue: | 770 |
Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
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BDBM20233 |
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BDBM20194 |
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Name | BDBM20233 |
Synonyms: | 4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamoyl)-3-carbamoylpropyl]carbamoyl}pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid | 40, Ac-pTyr-Leu-Pro-Gln-NHBn | CHEMBL194855 |
Type | Phosphopeptide |
Emp. Form. | C34H47N6O10P |
Mol. Mass. | 730.7449 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r| |
Structure |
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