| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
|---|
| Ligand | BDBM364613 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FLIPR Assay |
|---|
| IC50 | 1.22±n/a nM |
|---|
| Citation |  Lawrence, RM; Miller, MM; Seiffert, DA; Posy, SL; Wong, PC; Banville, J; Ruediger, EH; Deon, DH; Martel, A; Tremblay, F; Guy, J; Lavallée, J; Gagnon, M Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9862730 Publication Date 1/9/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteinase-activated receptor 4 |
|---|
| Name: | Proteinase-activated receptor 4 |
|---|
| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41145.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI0 |
|---|
| Residue: | 385 |
|---|
| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
|
|
|
|---|
| BDBM364613 |
|---|
| n/a |
|---|
| Name | BDBM364613 |
|---|
| Synonyms: | US9862730, Example 71 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H11N3O3S |
|---|
| Mol. Mass. | 301.32 |
|---|
| SMILES | COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
