Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM21410 |
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Substrate/Competitor | Fluorescein-labeled BAD peptide |
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Meas. Tech. | Fluorescence Polarization (FP) Assay and FL5.12 Cellular Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 6.1±1.2 nM |
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IC50 | 360±n/a nM |
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EC50 | 580±180 nM |
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Citation | Bruncko, M; Oost, TK; Belli, BA; Ding, H; Joseph, MK; Kunzer, A; Martineau, D; McClellan, WJ; Mitten, M; Ng, SC; Nimmer, PM; Oltersdorf, T; Park, CM; Petros, AM; Shoemaker, AR; Song, X; Wang, X; Wendt, MD; Zhang, H; Fesik, SW; Rosenberg, SH; Elmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem50:641-62 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM21410 |
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Fluorescein-labeled BAD peptide |
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Name: | Fluorescein-labeled BAD peptide |
Synonyms: | n/a |
Type: | fluorescein-labeled probe |
Mol. Mass.: | 3078.53 |
Organism: | n/a |
Description: | n/a |
Residue: | 25 |
Sequence: | NLWAAQRYGRELRRMSDK(FITC)FVD
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