Reaction Details |
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Target | ADP-ribosylhydrolase ARH3 |
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Ligand | BDBM371506 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ARH3 Assay |
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IC50 | >150000±n/a nM |
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Citation | McGonagle, AE; Jordan, A; Waszkowycz, B; Hutton, C; Waddell, I; Hitchin, JR; Smith, KM; Hamilton, NM 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG US Patent US10239843 Publication Date 3/26/2019 |
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More Info.: | Get all data from this article, Assay Method |
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ADP-ribosylhydrolase ARH3 |
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Name: | ADP-ribosylhydrolase ARH3 |
Synonyms: | ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38934.22 |
Organism: | Homo sapiens (Human) |
Description: | Q9NX46 |
Residue: | 363 |
Sequence: | MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
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BDBM371506 |
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n/a |
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Name | BDBM371506 |
Synonyms: | 1-[(2,4-Dimethylthiazol-5-yl)methyl]-N-[1-(fluoromethyl)cyclopropyl]-3-[(3-methylisoxazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide | US10239843, Example 616 |
Type | Small organic molecule |
Emp. Form. | C23H24FN5O5S2 |
Mol. Mass. | 533.596 |
SMILES | Cc1cc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)on1 |
Structure |
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