Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Lyn |
---|
Ligand | BDBM340099 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Lyn Enzyme Activity |
---|
EC50 | >1000±n/a nM |
---|
Citation | Barf, TA; Jans, CG; de Man, AP; Oubrie, AA; Raaijmakers, HC; Rewinkel, JB; Sterrenburg, JG; Wijkmans, JC 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors US Patent US10239883 Publication Date 3/26/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Lyn |
---|
Name: | Tyrosine-protein kinase Lyn |
Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
Type: | Protein |
Mol. Mass.: | 58575.92 |
Organism: | Homo sapiens (Human) |
Description: | P07948 |
Residue: | 512 |
Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
|
|
|
BDBM340099 |
---|
n/a |
---|
Name | BDBM340099 |
Synonyms: | (S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- enoyl)piperidin-2-yl)imidazo[1,5- a]pyrazin-1-yl)-N-(pyridazin-3- yl)benzamide | US10239883, Example 73 | US10934296, Example 73 | US9758524, Example 73 |
Type | Small organic molecule |
Emp. Form. | C28H31N9O2 |
Mol. Mass. | 525.6048 |
SMILES | CN(C)C\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cccnn2)c2c(N)nccn12 |r| |
Structure |
|