| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM375454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent US9907800 Publication Date 3/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM375454 |
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| n/a |
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| Name | BDBM375454 |
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| Synonyms: | US10358436, Example A164 | US9907800, Example A164 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29N5O2 |
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| Mol. Mass. | 491.5836 |
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| SMILES | CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)c1 |r| |
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| Structure | 
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