| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM375546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| IC50 | <100.0±n/a nM |
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| Citation |  Nacro, K; Duraiswamy, AJ; Chennamaneni, LR Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof US Patent US9908886 Publication Date 3/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 51342.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5 |
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| Residue: | 465 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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| BDBM375546 |
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| n/a |
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| Name | BDBM375546 |
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| Synonyms: | 4-(6-(4-(1,4-oxazepane-4-carbonyl)phenyl imidazo[1,2-a]pyridin-3-yl)benzonitrile | US9908886, Example 97 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N4O2 |
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| Mol. Mass. | 422.4785 |
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| SMILES | O=C(N1CCCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 |
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| Structure | 
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