| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII |
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| Ligand | BDBM23567 |
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| Substrate/Competitor | BDBM13553 |
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| Meas. Tech. | IC50 Value Determination |
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| IC50 | >50000±n/a nM |
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| Citation |  Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem51:3077-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Coagulation factor VII |
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| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM23567 |
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| BDBM13553 |
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| Name | BDBM23567 |
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| Synonyms: | 3-Carboxamide-coumarin deriv., 45 | 8-bromo-6-chloro-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11BrClNO3 |
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| Mol. Mass. | 392.631 |
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| SMILES | Cc1cccc(NC(=O)c2cc3cc(Cl)cc(Br)c3oc2=O)c1 |
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| Structure | 
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