| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SMYD3 |
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| Ligand | BDBM378462 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SMYD3 Biochemical Assay |
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| IC50 | 3.54±n/a nM |
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| Citation |  Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SMYD3 |
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| Name: | Histone-lysine N-methyltransferase SMYD3 |
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| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49101.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H7B4-2 |
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| Residue: | 428 |
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| Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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| BDBM378462 |
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| n/a |
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| Name | BDBM378462 |
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| Synonyms: | 6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluorobutyl)piperidin-4-yl)methyl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)indoline-5-carboxamide | US10266526, Compound 595 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34ClF3N4O4S |
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| Mol. Mass. | 591.086 |
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| SMILES | FC(F)(F)CCCN1CCC(CS(=O)(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)NC(=O)c2cc3CC(=O)Nc3cc2Cl)CC1 |r,TLB:12:15:18.17:22.21.20| |
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| Structure | 
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