Reaction Details |
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Target | Histone-lysine N-methyltransferase SMYD3 |
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Ligand | BDBM378477 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SMYD3 Biochemical Assay |
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IC50 | 23.8±n/a nM |
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Citation | Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase SMYD3 |
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Name: | Histone-lysine N-methyltransferase SMYD3 |
Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
Type: | Enzyme |
Mol. Mass.: | 49101.22 |
Organism: | Homo sapiens (Human) |
Description: | Q9H7B4-2 |
Residue: | 428 |
Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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BDBM378477 |
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n/a |
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Name | BDBM378477 |
Synonyms: | N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-5-ethylisothiazole-3-carboxamide | US10266526, Compound 610 |
Type | Small organic molecule |
Emp. Form. | C18H29N5O3S2 |
Mol. Mass. | 427.585 |
SMILES | CCc1cc(ns1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)N1CCC(N)CC1 |r,TLB:18:17:14.13:11.10.16| |
Structure |
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