Reaction Details |
| Report a problem with these data |
Target | Collagenase 3 |
---|
Ligand | BDBM24047 |
---|
Substrate/Competitor | BDBM23499 |
---|
Meas. Tech. | MMP Inhibition Assay |
---|
pH | 7.5±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 4.4±n/a nM |
---|
Citation | Xiang, JS; Hu, Y; Rush, TS; Thomason, JR; Ipek, M; Sum, PE; Abrous, L; Sabatini, JJ; Georgiadis, K; Reifenberg, E; Majumdar, M; Morris, EA; Tam, S Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Bioorg Med Chem Lett16:311-6 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Collagenase 3 |
---|
Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
BDBM24047 |
---|
BDBM23499 |
---|
Name | BDBM24047 |
Synonyms: | (2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-yl)methoxy]phenyl}benzene)sulfonamido]butanoic acid | biphenylsulfonamide carboxylate, 24 |
Type | Small organic molecule |
Emp. Form. | C27H27NO6S |
Mol. Mass. | 493.571 |
SMILES | CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(OCc2oc3ccccc3c2C)cc1)C(O)=O |r| |
Structure |
|