| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit alpha [F36L]/beta/gamma |
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| Ligand | BDBM24966 |
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| Substrate/Competitor | BDBM24961 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 41000±2000 nM |
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| IC50 | 342000±23000 nM |
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| Citation |  Vassiliou, S; Grabowiecka, A; Kosikowska, P; Yiotakis, A; Kafarski, P; Berlicki, L Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem51:5736-44 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Urease subunit alpha [F36L]/beta/gamma |
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| Name: | Urease subunit alpha [F36L]/beta/gamma |
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| Synonyms: | Urea Amidohydrolase | Urea Amidohydrolase-pv | Urease |
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| Type: | Heterotrimer of ureA, ureB and ureC subunits. Three heterotrimers associate to form the active enzyme. |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Urease subunit alpha [F36L] |
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| Synonyms: | URE1_PROMH | Urea Amidohydrolase Subunit alpha | ureC |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 60882.75 |
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| Organism: | Proteus vulgaris |
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| Description: | P17086[F36L] |
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| Residue: | 567 |
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| Sequence: | MKTISRQAYADMFGPTTGDRLRLADTELFLEIEKDLTTYGEEVKFGGGKVIRDGMGQSQV
VSAECVDVLITNAIILDYWGIVKADIGIKDGRIVGIGKAGNPDVQPNVDIVIGPGTEVVA
GEGKIVTAGGIDTHIHFICPQQAQEGLVSGVTTFIGGGTGPVAGTNATTVTPGIWNMYRM
LEAVDELPINVGLFGKGCVSQPEAIREQITAGAIGLKIHEDWGATPMAIHNCLNVADEMD
VQVAIHSDTLNEGGFYEETVKAIAGRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNP
TMPYTINTVDEHLDMLMVCHHLDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSD
SQAMGRVGEVILRTWQCAHKMKLQRGTLAGDSADNDNNRIKRYIAKYTINPALAHGIAHT
VGSIEKGKLADIVLWDPAFFGVKPALIIKGGMVAYAPMGDINAAIPTPQPVHYRPMYACL
GKAKYQTSMIFMSKAGIEAGVPEKLGLKSLIGRVEGCRHITKASMIHNNYVPHIELDPQT
YIVKADGVPLVCEPATELPMAQRYFLF
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| Component 2 |
| Name: | Urease subunit beta |
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| Synonyms: | UreB | Urea Amidohydrolase Subunit beta |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 12029.52 |
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| Organism: | Proteus vulgaris |
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| Description: | n/a |
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| Residue: | 108 |
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| Sequence: | MIPGEISVNQALGDIELNAGRETKIIQVANHGDRPVQVGSHYHFYEVNEALNFERESTLG
FRLNIPAGMAVRFEPGQSRTVELVAFAGKREIYGFHGKVMGKLESEKK
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| Component 3 |
| Name: | Urease subunit gamma |
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| Synonyms: | UreA | Urea Amidohydrolase Subunit gamma |
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| Type: | n/a |
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| Mol. Mass.: | 10908.21 |
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| Organism: | Proteus vulgaris |
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| Description: | n/a |
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| Residue: | 100 |
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| Sequence: | MELTPREKDKLLLFTAGLVAERRLAKGLKLNYPEAVALISCAIMEGAREGKTVAQLMSEG
RSVLAAEQVMEGVPEMIKDIQVECTFPDGTKLVSIHDPIV
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| BDBM24966 |
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| BDBM24961 |
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| Name | BDBM24966 |
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| Synonyms: | organophosphorus derivative, 7 | {[(2S)-2-amino-3-hydroxypropanamido]methyl}(methyl)phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C5H13N2O4P |
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| Mol. Mass. | 196.1415 |
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| SMILES | CP(O)(=O)CNC(=O)[C@@H](N)CO |r| |
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| Structure | 
|
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