Reaction Details |
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Target | Glucocorticoid receptor |
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Ligand | BDBM381532 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Evaluation |
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IC50 | <50±n/a nM |
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Citation | Pinkerton, AB; Hassig, CA; Jackson, MR; Ardecky, RJ; Pass, I Inhibitors of glucocorticoid receptor translocation US Patent US10272074 Publication Date 4/30/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Glucocorticoid receptor |
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Name: | Glucocorticoid receptor |
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
Type: | Enzyme |
Mol. Mass.: | 85656.87 |
Organism: | Homo sapiens (Human) |
Description: | P04150 |
Residue: | 777 |
Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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BDBM381532 |
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n/a |
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Name | BDBM381532 |
Synonyms: | 4-Chloro-1-(6-methoxy-pyrimidin- 4-ylmethyl)-3-methyl-1H- pyrazolo[3,4-b]pyridine-5- carboxylic acid (4-trifluoromethyl- phenyl)-amide | US10272074, Example 366 |
Type | Small organic molecule |
Emp. Form. | C21H16ClF3N6O2 |
Mol. Mass. | 476.839 |
SMILES | COc1cc(Cn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)ncn1 |
Structure |
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