| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 3 |
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| Ligand | BDBM381795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-based activity under Prompt Conditions |
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| IC50 | 2.00±n/a nM |
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| Citation |  Carreras, C; Charmot, D; Jacobs, JW; Labonte, E; Lewis, JG NHE3-binding compounds and methods for inhibiting phosphate transport US Patent US10272079 Publication Date 4/30/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 3 |
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| Name: | Sodium/hydrogen exchanger 3 |
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| Synonyms: | NHE3 | SL9A3_HUMAN | SLC9A3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92861.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_141050 |
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| Residue: | 834 |
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| Sequence: | MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
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| BDBM381795 |
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| n/a |
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| Name | BDBM381795 |
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| Synonyms: | US10272079, Compound 152 |
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| Type | Small organic molecule |
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| Emp. Form. | C54H66Cl4N8O12S2 |
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| Mol. Mass. | 1225.09 |
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| SMILES | CN(C)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)Nc1ccc(NC(=O)NCCOCCOCCNS(=O)(=O)c2ccc(O[C@@H]3[C@H](Cc4c3cc(Cl)cc4Cl)N(C)C)cc2)cc1 |r| |
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| Structure | 
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