| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 3 |
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| Ligand | BDBM381804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-based activity under Prompt Conditions |
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| IC50 | 0.631±n/a nM |
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| Citation |  Carreras, C; Charmot, D; Jacobs, JW; Labonte, E; Lewis, JG NHE3-binding compounds and methods for inhibiting phosphate transport US Patent US10272079 Publication Date 4/30/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 3 |
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| Name: | Sodium/hydrogen exchanger 3 |
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| Synonyms: | NHE-3 | Na(+)/H(+) exchanger 3 | Nhe3 | SL9A3_RAT | Slc9a3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93115.43 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_116967 |
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| Residue: | 831 |
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| Sequence: | MWHPALGPGWKPLLALAVAVTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWIL
VASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPI
VLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLL
FGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVT
GVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEM
LSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVI
WTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALV
VLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRA
FDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDA
ISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLE
QRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLE
SFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEE
ATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVP
SQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM
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| BDBM381804 |
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| n/a |
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| Name | BDBM381804 |
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| Synonyms: | US10272079, Compound 161 |
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| Type | Small organic molecule |
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| Emp. Form. | C83H111Cl6N13O19S3 |
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| Mol. Mass. | 1903.758 |
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| SMILES | CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCC(CCCNC(=O)NCCOCCOCCNS(=O)(=O)c2cccc(c2)[C@@H]2CN(C)Cc3c(Cl)cc(Cl)cc23)(CCCNC(=O)NCCOCCOCCNS(=O)(=O)c2cccc(c2)[C@@H]2CN(C)Cc3c(Cl)cc(Cl)cc23)NC(=O)COCC(O)=O)c2cc(Cl)cc(Cl)c2C1 |r| |
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| Structure | 
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