Reaction Details |
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Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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Ligand | BDBM386005 |
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Substrate/Competitor | n/a |
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Meas. Tech. | P70S6K Enzyme Assay |
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IC50 | 750±n/a nM |
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Citation | Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Ribosomal protein S6 kinase beta-1 [T412E] |
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Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59166.89 |
Organism: | Homo sapiens (Human) |
Description: | P23443[T412E] |
Residue: | 525 |
Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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BDBM386005 |
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n/a |
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Name | BDBM386005 |
Synonyms: | US10287300, Compound A12 | [2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl)-piperazin-1-yl]-2-(3-fluoro-4-trifluoromethylphenyl)-ethyl]-dimethylamine |
Type | Small organic molecule |
Emp. Form. | C21H26F4N6O |
Mol. Mass. | 454.4644 |
SMILES | CN(C)CC(N1CCN(CC1)c1ncnc2NCCOc12)c1ccc(c(F)c1)C(F)(F)F |
Structure |
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