| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Ligand | BDBM386014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P70S6K Enzyme Assay |
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| IC50 | 300±n/a nM |
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| Citation |  Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 [T412E] |
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| Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59166.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23443[T412E] |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM386014 |
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| n/a |
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| Name | BDBM386014 |
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| Synonyms: | 2-(4-fluorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl)-piperazin-1-yl]-ethylamine | US10287300, Compound A20 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23FN6O |
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| Mol. Mass. | 358.4132 |
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| SMILES | NCC(N1CCN(CC1)c1ncnc2NCCOc12)c1ccc(F)cc1 |
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| Structure | 
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