| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Ligand | BDBM386024 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P70S6K Enzyme Assay |
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| IC50 | 750±n/a nM |
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| Citation |  Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 [T412E] |
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| Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59166.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23443[T412E] |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM386024 |
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| n/a |
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| Name | BDBM386024 |
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| Synonyms: | 4-{4-[1-(4-chloro-phenyl)-2-(pyrrolidin-yl)-ethyl]-piperazin-1-yl}-7,8-dihydro-5H-pteridin-6-one | US10287300, Compound A30 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28ClN7O |
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| Mol. Mass. | 441.957 |
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| SMILES | Clc1ccc(cc1)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 |
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| Structure | 
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