| Reaction Details |
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 | Report a problem with these data |
| Target | Proline-rich AKT1 substrate 1 |
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| Ligand | BDBM386059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AKT Enzyme Assay |
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| IC50 | 300±n/a nM |
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| Citation |  Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proline-rich AKT1 substrate 1 |
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| Name: | Proline-rich AKT1 substrate 1 |
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| Synonyms: | 40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27368.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_664853 |
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| Residue: | 256 |
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| Sequence: | MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR
CLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQL
GISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQY
AKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLP
RPRLNTSDFQKLKRKY
|
|
|
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| BDBM386059 |
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| n/a |
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| Name | BDBM386059 |
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| Synonyms: | 4-(4-(1-(4-chloro-3-fluorophenyl)-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one | US10287300, Compound A61 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27ClFN7O |
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| Mol. Mass. | 459.947 |
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| SMILES | Fc1cc(ccc1Cl)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 |
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| Structure | 
|
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