Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386068

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

250±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10287305 Publication Date 5/14/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386068

n/a

Name

BDBM386068

Synonyms:

N-((2R,3S)-2-(((cis-4-(3,5- difluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 7 | US10508083, Example 7 | US11292766, Example 7

Type

Small organic molecule

Emp. Form.

C19H28F2N2O3S

Mol. Mass.

402.499

SMILES

CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:16.20,13.13,10.11,5.4,(7.34,-1.16,;6,-.39,;5.23,.95,;6.77,.95,;4.67,-1.16,;4.67,-2.7,;6,-3.47,;6,-5.01,;4.67,-5.78,;3.33,-5.01,;3.33,-3.47,;2,-2.7,;2,-1.16,;.67,-.39,;-.67,-1.16,;-2,-.39,;-2,1.15,;-.67,1.92,;.67,1.15,;-3.33,1.92,;-4.67,1.15,;-6,1.92,;-7.34,1.15,;-6,3.46,;-4.67,4.24,;-4.67,5.78,;-3.33,3.46,)|

Structure