Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386082

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

21.0±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10287305 Publication Date 5/14/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386082

n/a

Name

BDBM386082

Synonyms:

N-((2R,3S)-1-acetyl-2-(((cis-4-(2- (trifluoromethyl)phenyl)- cyclohexyl)oxy)methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 24 | US10508083, Example 24 | US11292766, Example 24

Type

Small organic molecule

Emp. Form.

C22H31F3N2O4S

Mol. Mass.

476.553

SMILES

CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:19.23,16.16,13.14,7.7,(,-4.23,;1.33,-5,;1.33,-6.54,;2.67,-4.24,;4,-5.01,;5.33,-4.24,;5.33,-2.7,;4,-1.93,;4,-.39,;5.33,.38,;6.67,-.39,;4.56,1.72,;6.1,1.72,;2.67,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;-1.33,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;,1.92,;-4,2.69,;-5.33,1.92,;-6.67,2.69,;-6.67,4.23,;-5.33,5.01,;-4,4.23,;-2.67,5,;-1.33,4.23,;-2.67,6.54,;-1.33,5.77,)|

Structure