Reaction Details | |||
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Target | Fibroblast growth factor receptor 1 | ||
Ligand | BDBM287048 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FGFR Family Enzymatic Activity Assay | ||
IC50 | 0.900±n/a nM | ||
Citation | Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 1 | |||
Name: | Fibroblast growth factor receptor 1 | ||
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
Type: | Receptor | ||
Mol. Mass.: | 91861.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11362 | ||
Residue: | 822 | ||
Sequence: |
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BDBM287048 | |||
n/a | |||
Name | BDBM287048 | ||
Synonyms: | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 64 | US11078199, Cpd 64 | US9567334, Example 64 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H38Cl2N6O5 | ||
Mol. Mass. | 645.577 | ||
SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@H]3CC[C@H](O)CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r,wU:19.19,wD:22.23,(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-4.67,-1.54,;-4.67,-3.08,;-6,-3.85,;-6,-5.39,;-7.34,-3.08,;-7.34,-1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| | ||
Structure |