Reaction Details | |||
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Target | Fibroblast growth factor receptor 1 | ||
Ligand | BDBM287519 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FGFR Family Enzymatic Activity Assay | ||
IC50 | 1.20±n/a nM | ||
Citation | Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 1 | |||
Name: | Fibroblast growth factor receptor 1 | ||
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
Type: | Receptor | ||
Mol. Mass.: | 91861.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11362 | ||
Residue: | 822 | ||
Sequence: |
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BDBM287519 | |||
n/a | |||
Name | BDBM287519 | ||
Synonyms: | 8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((3-(4-ethylpiperazin-1-yl)propyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 91 | US11078199, Cpd 91 | US9567334, Example 91 | US9815834, Compound 91 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H41Cl2N7O5 | ||
Mol. Mass. | 674.618 | ||
SMILES | CCN1CCN(CCCNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-10.28,-8.09,;-10.28,-6.55,;-8.95,-5.78,;-8.95,-4.24,;-7.61,-3.47,;-6.28,-4.24,;-4.94,-3.47,;-4.94,-1.93,;-3.61,-1.16,;-3.61,.38,;-2.28,1.15,;-2.28,2.69,;-.94,3.46,;.39,2.69,;1.72,3.46,;3.06,2.69,;4.39,3.46,;4.39,5,;3.06,5.77,;5.73,5.78,;5.73,7.32,;7.06,8.09,;7.06,5,;7.06,3.46,;8.39,2.69,;9.73,3.46,;5.73,2.69,;5.73,1.15,;3.06,1.15,;4.39,.38,;1.72,.38,;1.72,-1.16,;3.06,-1.93,;3.06,-3.47,;4.39,-4.24,;4.79,-5.72,;6.28,-5.32,;5.88,-3.84,;7.61,-6.09,;7.61,-7.63,;8.95,-5.32,;10.28,-6.09,;.39,1.15,;-.94,.38,;-6.28,-5.78,;-7.61,-6.55,)| | ||
Structure |