Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM387926 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FGFR Family Enzymatic Activity Assay | ||
| IC50 | 0.700±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM387926 | |||
| n/a | |||
| Name | BDBM387926 | ||
| Synonyms: | 1-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)amino)ethyl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(methylamino)-1,6-naphthyridin-2(1H)-one | US10294223, Cpd No. 153 | US11078199, Cpd 153 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33Cl2N5O5 | ||
| Mol. Mass. | 590.498 | ||
| SMILES | CNc1cc2n(CCN(CCOC)C3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-4,-5.71,;-2.67,-6.48,;-1.33,-5.71,;-1.33,-4.17,;,-3.4,;,-1.86,;-1.33,-1.09,;-2.67,-1.86,;-4,-1.09,;-5.33,-1.86,;-6.67,-1.09,;-8,-1.86,;-9.34,-1.09,;-4,.45,;-5.09,1.54,;-4,2.63,;-2.91,1.54,;-4,4.17,;-2.67,4.94,;-5.33,4.94,;-5.33,6.48,;1.33,-1.09,;1.33,.45,;2.67,-1.86,;2.67,-3.4,;1.33,-4.17,;1.33,-5.71,;,-6.48,;4,-1.09,;4,.45,;2.67,1.22,;5.33,1.22,;5.33,2.76,;6.67,3.53,;6.67,.45,;6.67,-1.09,;8,-1.86,;9.34,-1.09,;5.33,-1.86,;5.33,-3.4,)| | ||
| Structure | 
| ||