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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 2 | ||
| Ligand | BDBM287520 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition of FGFR2-Dependent Cell Growth | ||
| IC50 | 0.700±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 2 | |||
| Name: | Fibroblast growth factor receptor 2 | ||
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92015.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21802 | ||
| Residue: | 821 | ||
| Sequence: |
| ||
| BDBM287520 | |||
| n/a | |||
| Name | BDBM287520 | ||
| Synonyms: | 8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl)-2-amino-6-(2,6-dichloro-3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 114 | US11078199, Cpd 114 | US9567334, Example 114 | US9815834, Compound 114 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26Cl2N6O4 | ||
| Mol. Mass. | 533.407 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCN(C)C2CN(C2)C(=O)C=C)c1=O |(3.72,7.86,;2.39,7.09,;2.39,5.55,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;1.06,3.24,;1.06,4.78,;-.28,5.55,;-.28,2.47,;-1.61,3.24,;-2.94,2.47,;-4.28,3.24,;-5.61,2.47,;-5.61,.93,;-6.94,.16,;-4.28,.16,;-2.94,.93,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;-1.61,-4.46,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-.28,.93,;1.06,.16,)| | ||
| Structure | 
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