| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [342-460] |
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| Ligand | BDBM391515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BRD4 AlphaScreen Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Combs, AP; Maduskuie, Jr., TP; Falahatpisheh, N 1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins US Patent US9957268 Publication Date 5/1/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [342-460] |
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| Name: | Bromodomain-containing protein 4 [342-460] |
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| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 13783.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | a.a. 342-460 (BRD4-BD2) |
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| Residue: | 119 |
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| Sequence: | PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMS
TIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
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| BDBM391515 |
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| n/a |
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| Name | BDBM391515 |
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| Synonyms: | 2-[2-isopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4- yl)-3-oxo-2,3-dihydro-4H-1,4- benzoxazin-4-yl]acetamide | US10472358, Example 13 | US10781209, Example 13 | US11059821, Example 13 | US11702416, Example 13 | US9957268, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O5 |
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| Mol. Mass. | 424.4498 |
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| SMILES | COc1cc2N(CC(N)=O)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C |
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| Structure | 
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