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TargetBromodomain-containing protein 4 [42-168]
LigandBDBM391538
Substrate/Competitorn/a
Meas. Tech.BRD4 AlphaScreen Assay
IC50<100±n/a nM
Citation Combs, APMaduskuie, Jr., TPFalahatpisheh, N 1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins US Patent US9957268 Publication Date 5/1/2018
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 [42-168]
Name:Bromodomain-containing protein 4 [42-168]
Synonyms:BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (Human)
Description:O60885[42-168]
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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  Blast E-value cutoff:
BDBM391538
n/a
NameBDBM391538
Synonyms:2-isopropyl-N,N-dimethyl-8- (6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4- yl)-3-oxo-3,4-dihydro-2H-1,4- benzoxazine-6-carboxamide | US10472358, Example 34 | US10781209, Example 34 | US11059821, Example 34 | US11702416, Example 34 | US9957268, Example 34
TypeSmall organic molecule
Emp. Form.C22H24N4O4
Mol. Mass.408.4504
SMILESCC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(=O)N(C)C
Structure
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