Reaction Details |
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Target | Coagulation factor VII |
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Ligand | BDBM31475 |
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Substrate/Competitor | Spectrozyme-FVIIa |
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Meas. Tech. | TF-FVIIa Enzyme Inhibition Assay |
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pH | 7.2±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 29±n/a nM |
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Citation | Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores. Bioorg Med Chem17:3934-58 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Coagulation factor VII |
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Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM31475 |
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Spectrozyme-FVIIa |
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Name: | Spectrozyme-FVIIa |
Synonyms: | CH3SO2-D-CHA-But-Arg-pNA.AcOH | methanesulphonyl- D-cyclohexylalanyl-butyl-arginine p-nitroanilide acetate |
Type: | Chromogenic peptide substrate |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | n/a |
Residue: | 3 |
Sequence: | |