| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled bile acid receptor 1 |
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| Ligand | BDBM50266574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TGR5/CRE Luciferase Assay |
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| EC50 | 299±n/a nM |
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| Citation |  Charton, J; Deprez, B; Leroux, F; Staels, B; Muhr-Tailleux, A; Hennuyer, N; Lestavel, S; Lassalle, M; Dubanchet, B Imidazol- or 1,2,4-triazol-derivatives and their use US Patent US10323016 Publication Date 6/18/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled bile acid receptor 1 |
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| Name: | G-protein coupled bile acid receptor 1 |
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| Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 35260.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHO cells transiently transfected with hTGR5. |
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| Residue: | 330 |
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| Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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| BDBM50266574 |
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| n/a |
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| Name | BDBM50266574 |
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| Synonyms: | CHEMBL4081298 | US10323016, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28FN3O2S |
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| Mol. Mass. | 477.594 |
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| SMILES | COc1ccc(cc1OC)N(C)c1cnc(SCc2c(C)cccc2C)n1-c1ccc(F)cc1 |
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| Structure | 
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