Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50266572 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TGR5/CRE Luciferase Assay |
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EC50 | 370±n/a nM |
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Citation | Charton, J; Deprez, B; Leroux, F; Staels, B; Muhr-Tailleux, A; Hennuyer, N; Lestavel, S; Lassalle, M; Dubanchet, B Imidazol- or 1,2,4-triazol-derivatives and their use US Patent US10323016 Publication Date 6/18/2019 |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5 |
Type: | PROTEIN |
Mol. Mass.: | 35665.78 |
Organism: | Mus musculus |
Description: | ChEMBL_1475560 |
Residue: | 329 |
Sequence: | MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
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BDBM50266572 |
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n/a |
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Name | BDBM50266572 |
Synonyms: | CHEMBL4060122 | US10323016, Example 15 |
Type | Small organic molecule |
Emp. Form. | C26H22F5N3O2S |
Mol. Mass. | 535.529 |
SMILES | COc1ccc(cc1OC)N(C)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(cc1)C(F)(F)F |
Structure |
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