| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled bile acid receptor 1 |
|---|
| Ligand | BDBM398287 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TGR5/CRE Luciferase Assay |
|---|
| EC50 | 0.500±n/a nM |
|---|
| Citation |  Charton, J; Deprez, B; Leroux, F; Staels, B; Muhr-Tailleux, A; Hennuyer, N; Lestavel, S; Lassalle, M; Dubanchet, B Imidazol- or 1,2,4-triazol-derivatives and their use US Patent US10323016 Publication Date 6/18/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled bile acid receptor 1 |
|---|
| Name: | G-protein coupled bile acid receptor 1 |
|---|
| Synonyms: | GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35665.78 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1475560 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
|
|
|
|---|
| BDBM398287 |
|---|
| n/a |
|---|
| Name | BDBM398287 |
|---|
| Synonyms: | US10323016, Example 26 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27F3N3O6S2 |
|---|
| Mol. Mass. | 622.656 |
|---|
| SMILES | COc1ccc(cc1OC)N(C)c1cnc(SCc2c(F)cc(OCCCS([O-])(=O)=O)cc2F)n1-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
