| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [42-168] |
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| Ligand | BDBM209460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BRD4-H4 Tetraacetylated Peptide Inhibition AlphaScreen |
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| IC50 | 7.00±n/a nM |
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| Citation |  Engelhardt, H; Gianni, D; Smethurst, C Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors US Patent US10328074 Publication Date 6/25/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [42-168] |
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| Name: | Bromodomain-containing protein 4 [42-168] |
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| Synonyms: | BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 15054.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885[42-168] |
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| Residue: | 127 |
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| Sequence: | STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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| BDBM209460 |
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| n/a |
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| Name | BDBM209460 |
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| Synonyms: | US10328074, Example III-1 | US11077107, Example III-1 | US9266891, III-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N8 |
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| Mol. Mass. | 452.5541 |
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| SMILES | CN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 |
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| Structure | 
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