Compile Data Set for Download or QSAR

Found 221 hits with Last Name = 'gianni' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209487 (US10328074, Example III-28 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccc(F)cn1)N1CCOCC1 Show InChI InChI=1S/C25H27FN10O/c1-15(2)29-23-25-33-32-16(3)35(25)14-20(30-23)24-31-19-12-28-22(34-6-8-37-9-7-34)10-21(19)36(24)13-18-5-4-17(26)11-27-18/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209487 (US10328074, Example III-28 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccc(F)cn1)N1CCOCC1 Show InChI InChI=1S/C25H27FN10O/c1-15(2)29-23-25-33-32-16(3)35(25)14-20(30-23)24-31-19-12-28-22(34-6-8-37-9-7-34)10-21(19)36(24)13-18-5-4-17(26)11-27-18/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209487 (US10328074, Example III-28 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccc(F)cn1)N1CCOCC1 Show InChI InChI=1S/C25H27FN10O/c1-15(2)29-23-25-33-32-16(3)35(25)14-20(30-23)24-31-19-12-28-22(34-6-8-37-9-7-34)10-21(19)36(24)13-18-5-4-17(26)11-27-18/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209481 (US10328074, Example III-22 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-7-9-34-10-8-31)11-19(17)33(22)13-16-5-3-4-6-25-16/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209482 (US10328074, Example III-23 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-7-6-18(31-9-11-34-12-10-31)13-21(19)33(23)14-17-5-3-4-8-26-17/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242688 (US9422290, I-1) Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(C)CC2)c2nnc(C)n2n1 Show InChI InChI=1S/C20H27N7/c1-15-22-23-20-18(21-17-9-11-25(2)12-10-17)13-19(24-27(15)20)26(3)14-16-7-5-4-6-8-16/h4-8,13,17,21H,9-12,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242696 (US9422290, II-3) Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1[nH]c2ccccc2c1Cc1ccccc1 Show InChI InChI=1S/C27H29N7/c1-18-30-31-27-25(28-20-12-14-33(2)15-13-20)17-24(32-34(18)27)26-22(16-19-8-4-3-5-9-19)21-10-6-7-11-23(21)29-26/h3-11,17,20,28-29H,12-16H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242702 (US9422290, II-9) Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1 Show InChI InChI=1S/C23H28N8/c1-16-25-26-23-22(24-18-9-11-29(2)12-10-18)14-21(28-31(16)23)19-15-30(3)27-20(19)13-17-7-5-4-6-8-17/h4-8,14-15,18,24H,9-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242713 (US9422290, III-2) Show SMILES CCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1 Show InChI InChI=1S/C21H29N7/c1-4-27-12-10-18(11-13-27)22-19-14-20(25-28-16(2)23-24-21(19)28)26(3)15-17-8-6-5-7-9-17/h5-9,14,18,22H,4,10-13,15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242714 (US9422290, III-3) Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1 Show InChI InChI=1S/C22H31N7O/c1-17-24-25-22-20(23-19-9-11-28(12-10-19)13-14-30-3)15-21(26-29(17)22)27(2)16-18-7-5-4-6-8-18/h4-8,15,19,23H,9-14,16H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209474 (US10328074, Example III-15 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:43| Show InChI InChI=1S/C33H38N10O2/c1-21-17-29(44)38-39-30(21)24-9-10-28-26(18-24)36-32(43(28)19-23-7-5-4-6-8-23)27-20-42-22(2)37-40-33(42)31(35-27)34-25-11-13-41(14-12-25)15-16-45-3/h4-10,18,20-21,25H,11-17,19H2,1-3H3,(H,34,35)(H,38,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209481 (US10328074, Example III-22 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-7-9-34-10-8-31)11-19(17)33(22)13-16-5-3-4-6-25-16/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209482 (US10328074, Example III-23 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-7-6-18(31-9-11-34-12-10-31)13-21(19)33(23)14-17-5-3-4-8-26-17/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209474 (US10328074, Example III-15 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:43| Show InChI InChI=1S/C33H38N10O2/c1-21-17-29(44)38-39-30(21)24-9-10-28-26(18-24)36-32(43(28)19-23-7-5-4-6-8-23)27-20-42-22(2)37-40-33(42)31(35-27)34-25-11-13-41(14-12-25)15-16-45-3/h4-10,18,20-21,25H,11-17,19H2,1-3H3,(H,34,35)(H,38,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209481 (US10328074, Example III-22 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-7-9-34-10-8-31)11-19(17)33(22)13-16-5-3-4-6-25-16/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209482 (US10328074, Example III-23 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-7-6-18(31-9-11-34-12-10-31)13-21(19)33(23)14-17-5-3-4-8-26-17/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209474 (US10328074, Example III-15 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:43| Show InChI InChI=1S/C33H38N10O2/c1-21-17-29(44)38-39-30(21)24-9-10-28-26(18-24)36-32(43(28)19-23-7-5-4-6-8-23)27-20-42-22(2)37-40-33(42)31(35-27)34-25-11-13-41(14-12-25)15-16-45-3/h4-10,18,20-21,25H,11-17,19H2,1-3H3,(H,34,35)(H,38,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209457 (US10328074, Example II-1 | US11077107, Example II-...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc(c(C)n1Cc1ccccc1)-c1ccccc1 Show InChI InChI=1S/C24H23N7/c1-16-21(19-12-8-5-9-13-19)27-23(30(16)14-18-10-6-4-7-11-18)20-15-31-17(2)28-29-24(31)22(25-3)26-20/h4-13,15H,14H2,1-3H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209508 (US10328074, Example III-49 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-6-8-34-9-7-31)10-19(17)33(22)13-16-4-3-5-25-11-16/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242701 (US9422290, II-8) Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1 Show InChI InChI=1S/C25H32N8O/c1-18-27-28-25-24(26-20-9-11-32(12-10-20)13-14-34-3)16-23(30-33(18)25)21-17-31(2)29-22(21)15-19-7-5-4-6-8-19/h4-8,16-17,20,26H,9-15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209457 (US10328074, Example II-1 | US11077107, Example II-...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc(c(C)n1Cc1ccccc1)-c1ccccc1 Show InChI InChI=1S/C24H23N7/c1-16-21(19-12-8-5-9-13-19)27-23(30(16)14-18-10-6-4-7-11-18)20-15-31-17(2)28-29-24(31)22(25-3)26-20/h4-13,15H,14H2,1-3H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209508 (US10328074, Example III-49 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-6-8-34-9-7-31)10-19(17)33(22)13-16-4-3-5-25-11-16/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209457 (US10328074, Example II-1 | US11077107, Example II-...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc(c(C)n1Cc1ccccc1)-c1ccccc1 Show InChI InChI=1S/C24H23N7/c1-16-21(19-12-8-5-9-13-19)27-23(30(16)14-18-10-6-4-7-11-18)20-15-31-17(2)28-29-24(31)22(25-3)26-20/h4-13,15H,14H2,1-3H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209508 (US10328074, Example III-49 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-6-8-34-9-7-31)10-19(17)33(22)13-16-4-3-5-25-11-16/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209475 (US10328074, Example III-16 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:33| Show InChI InChI=1S/C26H25N9O/c1-15-11-22(36)31-32-23(15)18-9-10-21-19(12-18)29-25(35(21)13-17-7-5-4-6-8-17)20-14-34-16(2)30-33-26(34)24(27-3)28-20/h4-10,12,14-15H,11,13H2,1-3H3,(H,27,28)(H,31,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209485 (US10328074, Example III-26 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C26H29N9O/c1-17(2)28-24-26-32-31-18(3)34(26)16-22(29-24)25-30-21-8-7-20(33-10-12-36-13-11-33)14-23(21)35(25)15-19-6-4-5-9-27-19/h4-9,14,16-17H,10-13,15H2,1-3H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209475 (US10328074, Example III-16 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:33| Show InChI InChI=1S/C26H25N9O/c1-15-11-22(36)31-32-23(15)18-9-10-21-19(12-18)29-25(35(21)13-17-7-5-4-6-8-17)20-14-34-16(2)30-33-26(34)24(27-3)28-20/h4-10,12,14-15H,11,13H2,1-3H3,(H,27,28)(H,31,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209485 (US10328074, Example III-26 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C26H29N9O/c1-17(2)28-24-26-32-31-18(3)34(26)16-22(29-24)25-30-21-8-7-20(33-10-12-36-13-11-33)14-23(21)35(25)15-19-6-4-5-9-27-19/h4-9,14,16-17H,10-13,15H2,1-3H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209509 (US10328074, Example III-50 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-6-5-18(31-8-10-34-11-9-31)12-21(19)33(23)14-17-4-3-7-26-13-17/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209475 (US10328074, Example III-16 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C |t:33| Show InChI InChI=1S/C26H25N9O/c1-15-11-22(36)31-32-23(15)18-9-10-21-19(12-18)29-25(35(21)13-17-7-5-4-6-8-17)20-14-34-16(2)30-33-26(34)24(27-3)28-20/h4-10,12,14-15H,11,13H2,1-3H3,(H,27,28)(H,31,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209485 (US10328074, Example III-26 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 Show InChI InChI=1S/C26H29N9O/c1-17(2)28-24-26-32-31-18(3)34(26)16-22(29-24)25-30-21-8-7-20(33-10-12-36-13-11-33)14-23(21)35(25)15-19-6-4-5-9-27-19/h4-9,14,16-17H,10-13,15H2,1-3H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209509 (US10328074, Example III-50 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-6-5-18(31-8-10-34-11-9-31)12-21(19)33(23)14-17-4-3-7-26-13-17/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209509 (US10328074, Example III-50 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-6-5-18(31-8-10-34-11-9-31)12-21(19)33(23)14-17-4-3-7-26-13-17/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209460 (US10328074, Example III-1 | US11077107, Example II...) Show SMILES CN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 Show InChI InChI=1S/C26H28N8/c1-18-30-31-26-24(27-20-12-14-32(2)15-13-20)28-22(17-33(18)26)25-29-21-10-6-7-11-23(21)34(25)16-19-8-4-3-5-9-19/h3-11,17,20H,12-16H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209471 (US10328074, Example III-12 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCOCC1 Show InChI InChI=1S/C32H39N9O2/c1-23-36-37-32-30(33-25-10-12-38(13-11-25)14-17-42-2)34-28(22-40(23)32)31-35-27-9-8-26(39-15-18-43-19-16-39)20-29(27)41(31)21-24-6-4-3-5-7-24/h3-9,20,22,25H,10-19,21H2,1-2H3,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209491 (US10328074, Example III-32 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N(C)C Show InChI InChI=1S/C24H27N9/c1-15(2)26-22-24-30-29-16(3)32(24)14-20(27-22)23-28-19-10-9-18(31(4)5)12-21(19)33(23)13-17-8-6-7-11-25-17/h6-12,14-15H,13H2,1-5H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209460 (US10328074, Example III-1 | US11077107, Example II...) Show SMILES CN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 Show InChI InChI=1S/C26H28N8/c1-18-30-31-26-24(27-20-12-14-32(2)15-13-20)28-22(17-33(18)26)25-29-21-10-6-7-11-23(21)34(25)16-19-8-4-3-5-9-19/h3-11,17,20H,12-16H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209471 (US10328074, Example III-12 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCOCC1 Show InChI InChI=1S/C32H39N9O2/c1-23-36-37-32-30(33-25-10-12-38(13-11-25)14-17-42-2)34-28(22-40(23)32)31-35-27-9-8-26(39-15-18-43-19-16-39)20-29(27)41(31)21-24-6-4-3-5-7-24/h3-9,20,22,25H,10-19,21H2,1-2H3,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209491 (US10328074, Example III-32 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N(C)C Show InChI InChI=1S/C24H27N9/c1-15(2)26-22-24-30-29-16(3)32(24)14-20(27-22)23-28-19-10-9-18(31(4)5)12-21(19)33(23)13-17-8-6-7-11-25-17/h6-12,14-15H,13H2,1-5H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209460 (US10328074, Example III-1 | US11077107, Example II...) Show SMILES CN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 Show InChI InChI=1S/C26H28N8/c1-18-30-31-26-24(27-20-12-14-32(2)15-13-20)28-22(17-33(18)26)25-29-21-10-6-7-11-23(21)34(25)16-19-8-4-3-5-9-19/h3-11,17,20H,12-16H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209471 (US10328074, Example III-12 | US11077107, Example I...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCOCC1 Show InChI InChI=1S/C32H39N9O2/c1-23-36-37-32-30(33-25-10-12-38(13-11-25)14-17-42-2)34-28(22-40(23)32)31-35-27-9-8-26(39-15-18-43-19-16-39)20-29(27)41(31)21-24-6-4-3-5-7-24/h3-9,20,22,25H,10-19,21H2,1-2H3,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM209491 (US10328074, Example III-32 | US11077107, Example I...) Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N(C)C Show InChI InChI=1S/C24H27N9/c1-15(2)26-22-24-30-29-16(3)32(24)14-20(27-22)23-28-19-10-9-18(31(4)5)12-21(19)33(23)13-17-8-6-7-11-25-17/h6-12,14-15H,13H2,1-5H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PHQ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209453 (US10328074, Example I-5 | US11077107, Example I-5 ...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nn(C)c(C)c1Oc1ccccc1 Show InChI InChI=1S/C18H19N7O/c1-11-16(26-13-8-6-5-7-9-13)15(23-24(11)4)14-10-25-12(2)21-22-18(25)17(19-3)20-14/h5-10H,1-4H3,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209463 (US10328074, Example III-4 | US11077107, Example II...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 Show InChI InChI=1S/C28H32N8O/c1-20-32-33-28-26(29-22-12-14-34(15-13-22)16-17-37-2)30-24(19-35(20)28)27-31-23-10-6-7-11-25(23)36(27)18-21-8-4-3-5-9-21/h3-11,19,22H,12-18H2,1-2H3,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168]/Histone H4 (Homo sapiens (Human))	BDBM209507 (US10328074, Example III-48 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCN(C)CC1 Show InChI InChI=1S/C25H28N10/c1-17-30-31-25-23(26-2)28-21(16-34(17)25)24-29-20-7-6-19(33-11-9-32(3)10-12-33)13-22(20)35(24)15-18-5-4-8-27-14-18/h4-8,13-14,16H,9-12,15H2,1-3H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...				US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242699 (US9422290, II-6) Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1 Show InChI InChI=1S/C24H30N8O2/c1-17-27-28-23-22(26-18-9-11-31(12-10-18)13-14-33-3)15-21(29-32(17)23)20-16-25-30(2)24(20)34-19-7-5-4-6-8-19/h4-8,15-16,18,26H,9-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-168] (Homo sapiens (Human))	BDBM242700 (US9422290, II-7) Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1 Show InChI InChI=1S/C22H26N8O/c1-15-25-26-21-20(24-16-9-11-28(2)12-10-16)13-19(27-30(15)21)18-14-23-29(3)22(18)31-17-7-5-4-6-8-17/h4-8,13-14,16,24H,9-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...				US Patent US9422290 (2016) BindingDB Entry DOI: 10.7270/Q2R49PPG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209453 (US10328074, Example I-5 | US11077107, Example I-5 ...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nn(C)c(C)c1Oc1ccccc1 Show InChI InChI=1S/C18H19N7O/c1-11-16(26-13-8-6-5-7-9-13)15(23-24(11)4)14-10-25-12(2)21-22-18(25)17(19-3)20-14/h5-10H,1-4H3,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209463 (US10328074, Example III-4 | US11077107, Example II...) Show SMILES COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 Show InChI InChI=1S/C28H32N8O/c1-20-32-33-28-26(29-22-12-14-34(15-13-22)16-17-37-2)30-24(19-35(20)28)27-31-23-10-6-7-11-25(23)36(27)18-21-8-4-3-5-9-21/h3-11,19,22H,12-18H2,1-2H3,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM209480 (US10328074, Example III-21 | US11077107, Example I...) Show SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCN(C)CC1 Show InChI InChI=1S/C25H28N10/c1-17-30-31-25-23(26-2)28-21(16-34(17)25)24-29-20-8-7-19(33-12-10-32(3)11-13-33)14-22(20)35(24)15-18-6-4-5-9-27-18/h4-9,14,16H,10-13,15H2,1-3H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...				Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2
					More data for this Ligand-Target Pair

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