Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM34142 |
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Substrate/Competitor | BDBM21342 |
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Meas. Tech. | 5-HT6 Binding Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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Ki | 16±n/a nM |
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Comments | agonist. |
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Citation | Alcalde, E; Mesquida, N; López-Pérez, S; Frigola, J; Mercè, R; Holenz, J; Pujol, M; Hernández, E Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts. Bioorg Med Chem17:7387-97 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM34142 |
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BDBM21342 |
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Name | BDBM34142 |
Synonyms: | 2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL267615 | EDMT | EMDT | [2-(2-ethyl-5-methoxy-1H-indol-3-yl)ethyl]dimethylamine, 6 |
Type | Small organic molecule |
Emp. Form. | C15H22N2O |
Mol. Mass. | 246.348 |
SMILES | CCc1[nH]c2ccc(OC)cc2c1CCN(C)C |
Structure |
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