| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM35704 |
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| Substrate/Competitor | BDBM35667 |
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| Meas. Tech. | Binding Affinity Assay (Ki) and cAMP Accumulation Activity Assay (EC50) |
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| pH | 7.4±n/a |
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| Temperature | 296.15±n/a K |
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| Ki | 16±n/a nM |
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| EC50 | 1100±n/a nM |
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| Comments | AMP accumulation max activity = 59.3 %. |
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| Citation |  Tsukamoto, I; Koshio, H; Akamatsu, S; Kuramochi, T; Saitoh, C; Yatsu, T; Yanai-Inamura, H; Kitada, C; Yamamoto, E; Sakamoto, S; Tsukamoto, S Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V(2) receptor agonists. Bioorg Med Chem16:9524-35 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM35704 |
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| BDBM35667 |
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| Name | BDBM35704 |
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| Synonyms: | 5H-1-benzazepin-5-ylidene acetamide, 10k |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29ClF2N4O2 |
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| Mol. Mass. | 551.027 |
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| SMILES | CC1CCCN1c1ccc(C(=O)N2CCC(F)(F)\C(=C/C(=O)NCc3ccccn3)c3ccccc23)c(Cl)c1 |
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| Structure | 
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