Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
LigandBDBM36436
Substrate/CompetitorBDBM22111
Meas. Tech.MTAN Inhibition Assay
pH7.5±0
Temperature298.15±0 K
Ki 0.208±46 nM
Citation Gutierrez, JA; Crowder, T; Rinaldo-Matthis, A; Ho, MC; Almo, SC; Schramm, VL Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nat Chem Biol5:251-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Name:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:Enzyme
Mol. Mass.:24347.14
Organism:Escherichia coli (strain K12)
Description:P0AF12
Residue:232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36436
BDBM22111
NameBDBM36436
Synonyms:(3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 9 | (3R,4S)-4-(1-Butylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine, 9 | CID11393519
TypeSmall organic molecule
Emp. Form.C16H25N5OS
Mol. Mass.335.468
SMILESCCCCSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: