Reaction Details |
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Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Ligand | BDBM36497 |
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Substrate/Competitor | BDBM22111 |
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Meas. Tech. | Enzyme Activity Assay |
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pH | 7.5±0 |
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Temperature | 298.15±0 K |
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Kd | 0.024±0.0 nM |
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Citation | Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
Synonyms: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase (MTAN) |
Type: | Enzyme |
Mol. Mass.: | 24739.13 |
Organism: | Neisseria meningitidis |
Description: | C6S634 |
Residue: | 233 |
Sequence: | MSLKTVTVIGAMEQEIELLREMMENVKAVSFGKFAAYEGELAGKRMVLALSGIGKVNAAV
ATAWLIHQFAPDCVINTGSAGGLGKGLKVGDVVVGTEIAHHDVDVTAFGYVWGQVPQLPA
RFASDGILIETAKRAARTFEGAAVEQGLIVSGDRFVHSSEGVAEIRKHFPEVKAVEMEAA
AIAQTCHQLETPFVIIRAVSDSADEKADISFDEFLKTAAANSAKMVAEIVKSL
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BDBM36497 |
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BDBM22111 |
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Name | BDBM36497 |
Synonyms: | CHEMBL191436 | DADMe-ImmA-Bn |
Type | Small organic molecule |
Emp. Form. | C19H23N5OS |
Mol. Mass. | 369.484 |
SMILES | Nc1ncnc2c(CN3CC(O)C(CSCc4ccccc4)C3)c[nH]c12 |
Structure |
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