Reaction Details |
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Target | Aminodeoxyfutalosine nucleosidase |
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Ligand | BDBM36498 |
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Substrate/Competitor | BDBM22111 |
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Meas. Tech. | Enzyme Activity Assay |
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pH | 7.5±0 |
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Temperature | 298.15±0 K |
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Kd | 0.570±0.0 nM |
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Citation | Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aminodeoxyfutalosine nucleosidase |
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Name: | Aminodeoxyfutalosine nucleosidase |
Synonyms: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 6-amino-6-deoxyfutalosine N-ribosylhydrolase | MTN | Methylthioadenosine Nucleosidase (MTAN) |
Type: | Enzyme |
Mol. Mass.: | 25200.22 |
Organism: | Helicobacter pylori |
Description: | O24915 |
Residue: | 231 |
Sequence: | MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTL
TTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAI
FIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASV
AFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
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BDBM36498 |
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BDBM22111 |
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Name | BDBM36498 |
Synonyms: | DADMe-ImmA-p-ClPh |
Type | Small organic molecule |
Emp. Form. | C18H20ClN5OS |
Mol. Mass. | 389.902 |
SMILES | Nc1ncnc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12 |
Structure |
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