Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [514-612] |
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Ligand | BDBM1247 |
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Substrate/Competitor | decapeptide substrate |
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Meas. Tech. | Protease Inhibition Assay |
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pH | 5.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 42±n/a nM |
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Citation | Beaulieu, PL; Wernic, D; Abraham, A; Anderson, PC; Bogri, T; Bousquet, Y; Croteau, G; Guse, I; Lamarre, D; Liard, F; Paris, W; Thibeault, D; Pav, S; Tong, L Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. J Med Chem40:2164-76 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [514-612] |
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Name: | Dimer of Gag-Pol polyprotein [514-612] |
Synonyms: | HIV-2 Protease |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [514-612] |
Synonyms: | HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10718.25 |
Organism: | Human immunodeficiency virus type 2 |
Description: | P04584[514-612] |
Residue: | 99 |
Sequence: | PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
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Component 2 |
Name: | Gag-Pol polyprotein [514-612] |
Synonyms: | HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10718.25 |
Organism: | Human immunodeficiency virus type 2 |
Description: | P04584[514-612] |
Residue: | 99 |
Sequence: | PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
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BDBM1247 |
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decapeptide substrate |
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Name: | decapeptide substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 1417.08 |
Organism: | n/a |
Description: | n/a |
Residue: | 12 |
Sequence: | |