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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM264126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.50±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent US9714234 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM264126 | |||
| n/a | |||
| Name | BDBM264126 | ||
| Synonyms: | 4-(3-(8-Fluoro-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (Mixtures of Two Interconverting diastereomers) | US9714234, 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H25FN4O4 | ||
| Mol. Mass. | 536.553 | ||
| SMILES | Cc1c(cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.89,,;1.55,-.77,;.22,,;-1.12,-.77,;-1.12,-2.31,;.22,-3.08,;1.55,-2.31,;2.89,-3.08,;2.89,-4.62,;1.55,-5.39,;4.22,-5.39,;5.55,-4.62,;6.89,-5.39,;6.89,-6.93,;8.22,-4.62,;8.22,-3.08,;6.89,-2.31,;5.55,-3.08,;4.22,-2.31,;4.22,-.77,;.22,1.54,;1.55,2.31,;1.55,3.85,;.22,4.62,;.22,6.16,;1.55,6.93,;-1.12,6.93,;-1.12,3.85,;-2.58,4.33,;-3.49,3.08,;-5.02,2.92,;-5.64,1.51,;-4.74,.27,;-3.21,.43,;-2.58,1.83,;-1.12,2.31,;-7.13,1.11,;-7.53,-.37,;-6.04,.02,;-8.22,2.2,)| | ||
| Structure | 
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