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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM264138 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.940±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent US9714234 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
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| BDBM264138 | |||
| n/a | |||
| Name | BDBM264138 | ||
| Synonyms: | 5-Chloro-2-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrido[1,2-c]pyrimidine-1,3(2H)-dione(racemic) | US9714234, 13 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22BClN2O4 | ||
| Mol. Mass. | 412.674 | ||
| SMILES | Cc1c(cccc1-n1c(=O)cc2c(Cl)cccn2c1=O)B1OC(C)(C)C(C)(C)O1 |(-.18,.84,;-1.51,.07,;-2.85,.84,;-4.18,.07,;-4.18,-1.47,;-2.85,-2.24,;-1.51,-1.47,;-.18,-2.24,;-.18,-3.78,;-1.51,-4.55,;1.16,-4.55,;2.49,-3.78,;3.82,-4.55,;3.82,-6.09,;5.16,-3.78,;5.16,-2.24,;3.82,-1.47,;2.49,-2.24,;1.16,-1.47,;1.16,.07,;-2.85,2.38,;-4.09,3.29,;-3.62,4.75,;-5.16,4.75,;-4.39,6.09,;-2.08,4.75,;-1.31,6.09,;-.54,4.75,;-1.6,3.29,)| | ||
| Structure | 
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