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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM264149 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.590±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent US9714234 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
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| BDBM264149 | |||
| n/a | |||
| Name | BDBM264149 | ||
| Synonyms: | 8-Fluoro-1-methyl(d3)-3-(S)-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)quinazoline-2,4(1H,3H)-dione (I-24), and | US9714234, 24 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24BFN2O4 | ||
| Mol. Mass. | 410.246 | ||
| SMILES | Cc1c(cccc1-n1c(=O)n(C)c2c(F)cccc2c1=O)B1OC(C)(C)C(C)(C)O1 |(-.08,9.2,;-1.42,8.43,;-2.75,9.2,;-4.08,8.43,;-4.08,6.89,;-2.75,6.12,;-1.42,6.89,;-.08,6.12,;-.08,4.58,;-1.42,3.81,;1.25,3.81,;1.25,2.27,;2.58,4.58,;3.92,3.81,;3.92,2.27,;5.25,4.58,;5.25,6.12,;3.92,6.89,;2.58,6.12,;1.25,6.89,;1.25,8.43,;-2.75,10.74,;-4,11.64,;-3.52,13.11,;-4.29,14.44,;-5.01,13.5,;-1.98,13.11,;-1.98,14.65,;-.49,13.5,;-1.5,11.64,)| | ||
| Structure | 
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