Reaction Details |
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Target | Gag-Pol polyprotein [588-1027]/[588-1147] |
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Ligand | BDBM1361 |
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Substrate/Competitor | RNA template(1080) : deoxy-oligo primer(18) |
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Meas. Tech. | HIV-1 RT Assay |
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pH | 7.7±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 130±n/a nM |
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Citation | Mertens, A; Zilch, H; Konig, B; Schafer, W; Poll, T; Kampe, W; Seidel, H; Leser, U; Leinert, H Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity. J Med Chem36:2526-35 (1993) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [588-1027]/[588-1147] |
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Name: | Gag-Pol polyprotein [588-1027]/[588-1147] |
Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase |
Type: | Protein Complex |
Mol. Mass.: | 115684 |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147] |
Synonyms: | HIV-1 Reverse Transcriptase Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64486.41 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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Component 2 |
Name: | Gag-Pol polyprotein [588-1027] |
Synonyms: | HIV-1 Reverse Transcriptase Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51337.13 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1027] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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BDBM1361 |
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RNA template(1080) : deoxy-oligo primer(18) |
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Name: | RNA template(1080) : deoxy-oligo primer(18) |
Synonyms: | n/a |
Type: | RNA-DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | 1 ug of HIV-1 template RNA (1080 nucleotides) and 20 ng of 18mer-deoxy-oligo primer were annealed by heating to 90°C and slowly cooling to 37°C. |
Residue: | 3 |
Sequence: | |