Reaction Details | |||
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Target | Solute carrier family 12 member 5 | ||
Ligand | BDBM43868 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 | ||
EC50 | 181000±n/a nM | ||
Citation | PubChem, PC Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 PubChem Bioassay(2009)[AID] | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Solute carrier family 12 member 5 | |||
Name: | Solute carrier family 12 member 5 | ||
Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 126185.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_828024 | ||
Residue: | 1139 | ||
Sequence: |
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BDBM43868 | |||
n/a | |||
Name | BDBM43868 | ||
Synonyms: | 3-[2-[4-[bis(4-fluorophenyl)methylene]piperidino]ethyl]-2-thioxo-1H-quinazolin-4-one | 3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one | 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one | DIACYLGLYCEROL KINASE INHIBITOR II | MLS000069510 | R 59949 | SMR000058550 | cid_657356 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H25F2N3OS | ||
Mol. Mass. | 489.579 | ||
SMILES | Fc1ccc(cc1)C(=C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1)c1ccc(F)cc1 |(8.41,-6.25,;8.41,-4.71,;9.75,-3.94,;9.75,-2.4,;8.41,-1.63,;7.08,-2.4,;7.08,-3.94,;8.41,-.09,;9.75,.68,;9.75,2.22,;11.08,2.99,;12.42,2.22,;13.75,2.99,;15.08,2.22,;16.42,2.99,;16.42,4.53,;15.08,5.3,;17.75,5.3,;19.08,4.53,;20.46,5.35,;21.86,4.56,;21.86,2.96,;20.46,2.16,;19.08,2.99,;17.75,2.22,;17.75,.68,;12.42,.68,;11.08,-.09,;7.08,.68,;5.75,-.09,;4.41,.68,;4.41,2.22,;3.08,2.99,;5.75,2.99,;7.08,2.22,)| | ||
Structure |