| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Ligand | BDBM267060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PFKFB4 Assay |
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| IC50 | 5200±n/a nM |
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| Citation |  Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent US9718809 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Synonyms: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 54039.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16877 |
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| Residue: | 469 |
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| Sequence: | MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
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| BDBM267060 |
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| n/a |
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| Name | BDBM267060 |
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| Synonyms: | Tetrahydrofuran-3-yl 4-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}-2-hydroxybenzoate | US9718809, 67 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13Cl2NO6S2 |
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| Mol. Mass. | 438.303 |
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| SMILES | Oc1cc(NS(=O)(=O)c2cc(Cl)sc2Cl)ccc1C(=O)OC1CCOC1 |
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| Structure | 
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