Ki Summary

Reaction Details

Report a problem with these data

Target

Mitochondrial import inner membrane translocase subunit TIM23

Ligand

BDBM78087

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.

IC50

9860±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mitochondrial import inner membrane translocase subunit TIM23

Name:

Mitochondrial import inner membrane translocase subunit TIM23

Synonyms:

MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

23245.32

Organism:

Saccharomyces cerevisiae S288c

Description:

gi_285814664

Residue:

222

Sequence:

MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHP
LAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQG
LQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIG
AGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK

BDBM78087

n/a

Name

BDBM78087

Synonyms:

2-[4-(4-methylphenyl)sulfonylimino-1-oxo-2-naphthalenyl]-3-oxobutanoic acid methyl ester | 3-keto-2-(1-keto-4-tosylimino-2-naphthyl)butyric acid methyl ester | MLS000521425 | SMR000131833 | cid_9551443 | methyl 2-[4-(4-methylphenyl)sulfonylimino-1-oxidanylidene-naphthalen-2-yl]-3-oxidanylidene-butanoate | methyl 2-[4-(4-methylphenyl)sulfonylimino-1-oxonaphthalen-2-yl]-3-oxobutanoate

Type

Small organic molecule

Emp. Form.

C22H19NO6S

Mol. Mass.

425.454

SMILES

COC(=O)C(C(C)=O)=C1C=C(NS(=O)(=O)c2ccc(C)cc2)c2ccccc2C1=O |w:8.30,t:9|

Structure