Ki Summary

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Target

DNA dC->dU-editing enzyme APOBEC-3G

Ligand

BDBM80217

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay

Temperature

298.15±n/a K

IC50

2750±n/a nM

Comments

extracted

Citation

PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA dC->dU-editing enzyme APOBEC-3G

Name:

DNA dC->dU-editing enzyme APOBEC-3G

Synonyms:

ABC3G_HUMAN | APOBEC3G

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46419.54

Organism:

Homo sapiens (Human)

Description:

gi_13399304

Residue:

384

Sequence:

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
YYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRG
FLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFIS
KNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQP
WDGLDEHSQDLSGRLRAILQNQEN

BDBM80217

n/a

Name

BDBM80217

Synonyms:

4-[(3,5-dimethyl-1-phenyl-4-pyrazolyl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenyl-pyrazol-4-yl)methyleneamino]-3-(4-pyridyl)-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenyl-pyrazol-4-yl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenylpyrazol-4-yl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-{[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]amino}-5-(4-pyridinyl)-4H-1,2,4-triazole-3-thiol | MLS000677596 | SMR000271759 | cid_1290540

Type

Small organic molecule

Emp. Form.

C19H17N7S

Mol. Mass.

375.45

SMILES

Cc1nn(c(C)c1C=Nn1c(n[nH]c1=S)-c1ccncc1)-c1ccccc1 |w:8.9|

Structure