| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM83216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) |
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| IC50 | 4736±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | Beta lactamase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31513.38 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | gi_114881106 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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|
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| BDBM83216 |
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| n/a |
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| Name | BDBM83216 |
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| Synonyms: | 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carbonitrile | 3-amino-4-(4-chlorophenyl)-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarbonitrile | 3-amino-4-(4-chlorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carbonitrile | 3-azanyl-4-(4-chlorophenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonitrile | MLS000324481 | SMR000160398 | cid_1005239 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H10ClN3S2 |
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| Mol. Mass. | 367.875 |
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| SMILES | Nc1c(sc2nc(cc(-c3ccc(Cl)cc3)c12)-c1cccs1)C#N |
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| Structure | 
|
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