| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM51704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) |
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| IC50 | 3732±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | Beta lactamase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31513.38 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | gi_114881106 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM51704 |
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| n/a |
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| Name | BDBM51704 |
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| Synonyms: | (2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenylacetic acid [2-oxo-4-(trifluoromethyl)-1-benzopyran-7-yl] ester | (2S)-2-phenyl-2-(tosylamino)acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester | 2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl {[(4-methylphenyl)sulfonyl]amino}(phenyl)acetate | MLS000575791 | SMR000196826 | [2-oxidanylidene-4-(trifluoromethyl)chromen-7-yl] (2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenyl-ethanoate | [2-oxo-4-(trifluoromethyl)chromen-7-yl] (2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenylacetate | cid_1326324 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18F3NO6S |
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| Mol. Mass. | 517.474 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)N[C@H](C(=O)Oc1ccc2c(cc(=O)oc2c1)C(F)(F)F)c1ccccc1 |
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| Structure | 
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